Nebivolol → HCID 9933004, compound

HRID 473062Notes

Reaction equation

HRID 473062 reaction equation
[CH:1]1[C:6]([F:7])=[CH:5][C:4]2[CH2:8][CH2:9][CH:10]([CH:12]([OH:29])[CH2:13][NH:14][CH2:15][CH:16]([OH:28])[CH:17]3[O:26][C:25]4[CH:24]=[CH:23][C:22]([F:27])=[CH:21][C:20]=4[CH2:19][CH2:18]3)[O:11][C:3]=2[CH:2]=1.[ClH:30].Cl>>[CH:23]1[C:22]([F:27])=[CH:21][C:20]2[CH2:19][CH2:18][CH:17]([CH:16]([OH:28])[CH2:15][NH:14][CH2:13][CH:12]([OH:29])[CH:10]3[O:11][C:3]4[CH:2]=[CH:1][C:6]([F:7])=[CH:5][C:4]=4[CH2:8][CH2:9]3)[O:26][C:25]=2[CH:24]=1.[ClH:30]

Participants

3

Reactant 2

HCID 71301NebivololHCID 21225539hydrochloric acid HCl

Product 1

HCID 9933004HCID 9933004, compound

Procedure

In a preferred embodiment the said form is obtained by conventional spray drying technique using a LabPlant SPD-005® spray drier. Nebivolol hydrochloride is dissolved in alcohol such as methanol under heating to obtain a clear solution or adjust pH below 2.0 of nebivolol base solution/suspension in alcohol using aqueous HCl/Alcoholic HCl/HCl gas, which is then spray dried for a period of 2 to 5 hours, and further isolating nebivolol hydrochloride Form T1.

Workup

  1. customIn a preferred embodiment the said form is obtained by conventional spray
  2. customdrying technique
  3. dissolutionNebivolol hydrochloride is dissolved in alcohol such as methanol
  4. temperatureunder heating
  5. customto obtain a clear solution
  6. customis then spray dried for a period of 2 to 5 hours

Sources & evidence

ORD record
ord-1f99891c7b164bd8893188ba6b3c37f3
Source dataset
uspto-grants-2014_01
Patent number
US08633241B2

Reaction notes

Loading…