Thionyl Chloride → (S)-N-(5-(3-(chloromethyl)-5-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide

Participants

Reaction Steps

To a solution of (S)-N-(5-(3-(hydroxymethyl)-5-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide (1.053 mmol, 450 mg) in CH2Cl2 (8 mL) was added Thionyl chloride (2.316 mmol, 0.169 mL, 276 mg) and the whole was stirred for 2 h at RT before the reaction mixture was concentrated under reduced pressure and re-dissovled in DCM. The process was repeated ×4 to drive off the excess thionyl chloride. The material was used immediately in the next reaction.

Provenance & Evidence