Methyl iodide → HCID 66609624, compound

Participants

Reaction Steps

To 7-bromo-2-(difluoro(5-fluoropyridin-2-yl)methyl)quinazoline-4-thiol (500 mg, 1.29 mmol) in isopropanol (10 mL) were added 1N NaOH (1.94 mL, 1.94 mmol) and iodomethane (0.097 mL, 1.55 mmol) and the mixture was stirred at rt for 30 min. A brown solid formed, which was collected by filtration and washed with MeOH to afford 7-bromo-2-(difluoro(5-fluoropyridin-2-yl)methyl)-4-(methylthio)quinazoline (0.373 g, 72%). 1H NMR (300 MHz, CDCl3) δ 8.45-8.51 (m, 1H), 8.26-8.32 (m, 1H), 7.93-8.03 (m, 2H), 7.74 (dd, J=1.9, 8.9 Hz, 1H), 7.54-7.65 (m, 1H), 2.61 (s, 3H); LC-MS (ESI) m/z 400/402 (M+H)+.

Provenance & Evidence