反应详情

温度

80 °C

13.0 g of (2S)-1-(trityloxy)-5-vinyl-6-heptene-2,5-diol and 57.2 g of toluenesulfonyl chloride were dissolved in 200 ml pyridine, and stirred at 80° C. overnight. After the reaction was completed, water was added thereto, and it was stirred at room temperature for 10 min. After extracting twice with ethyl acetate, washed with brine, and dried over magnesium sulfate. The solvent was removed, and the resulting residue was dissolved in toluene. After the solvent was removed again, the resulting residue was purified by silica gel column chromatography to give 5.88 g of (5R)-5-[(trityloxy)methyl]-2,2-divinyltetrahydrofuran.

1. stirringit was stirred at room temperature for 10 min
2. extractionAfter extracting twice with ethyl acetate
3. washwashed with brine
4. dry with materialdried over magnesium sulfate
5. customThe solvent was removed
6. dissolutionthe resulting residue was dissolved in toluene
7. customAfter the solvent was removed again
8. customthe resulting residue was purified by silica gel column chromatography