HCID 54759636, compound → Ilorasertib

HRID 473293Notes

Reaction equation

HRID 473293 reaction equation
Cl.[NH2:2][C:3]1[C:8]2[C:9]([C:12]3[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[CH:23]=4)=[O:20])=[CH:14][CH:13]=3)=[CH:10][S:11][C:7]=2[C:6]([C:29]2[CH:30]=[N:31][N:32]([CH2:34][CH2:35][OH:36])[CH:33]=2)=[CH:5][N:4]=1>O>[NH2:2][C:3]1[C:8]2[C:9]([C:12]3[CH:13]=[CH:14][C:15]([NH:18][C:19]([NH:21][C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[CH:23]=4)=[O:20])=[CH:16][CH:17]=3)=[CH:10][S:11][C:7]=2[C:6]([C:29]2[CH:30]=[N:31][N:32]([CH2:34][CH2:35][OH:36])[CH:33]=2)=[CH:5][N:4]=1

Participants

3

Reactant 1

HCID 54759636HCID 54759636, compound

Product 1

HCID 46207586Ilorasertib

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

There is further provided a process for preparing N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea HCl in a solid crystalline form, wherein the crystalline form is Form III comprising: a) providing a mixture comprising (i) N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea free base solid, water, an alcohol, and hydrochloric acid; and b) causing N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea HCl crystalline Form III to exist in the mixture.

Workup

  1. customThere is further provided a process

Sources & evidence

ORD record
ord-1ddb03313e154e4a918c202b8c98c452
Source dataset
uspto-grants-2014_01
Patent number
US08633317B2

Reaction notes

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