Methanesulfonic Acid → HCID 54759637, compound

Participants

Reaction Conditions

Reaction Steps

N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea free base solid (26 mg) was suspended in ethyl acetate (100 μL) at 40° C. with magnetic stirring. Methanesulfonic acid (6.6 μL, 4 M) was slowly added to A-968660 free base suspension at 40° C. with magnetic stirring. Amorphous material precipitated upon addition of the acid solution. Additional ethyl acetate (250 μL) was added and the suspension was stirred at 40° C. for 30 minutes. Solid was collected by centrifuge filtration.

Provenance & Evidence