Maleic Acid → HCID 54759819, compound

Participants

Reaction Steps

N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea free base solid (27 mg) was suspended in dimethylformamide (125 μL) at 40° C. with magnetic stirring. Maleic acid solution (120 μL, 0.5 M) was then slowly added to A-968660 free base suspension at 50° C. with magnetic stirring. Crystallization was observed upon complete addition of the acid solution. Solid was collected by centrifuge filtration.

Provenance & Evidence