1336910-19-0 → HCID 67465671, compound

HRID 473313Notes

Reaction equation

HRID 473313 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([F:13])[CH2:11][CH2:10][CH2:9][NH:8][C:7]1=[O:12])=[O:5])[CH3:2]>C(O)C>[F:13][C@@:6]1([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:11][CH2:10][CH2:9][NH:8][C:7]1=[O:12]

Participants

3

Reactant 1

HCID 674026591336910-19-0

Product 1

HCID 67465671HCID 67465671, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Samples were prepared in batches according to the following method: ethyl-3-fluoro-2-oxo-3-piperidinecarboxylate (25 g) was dissolved in ethanol (450 ml) with gentle heating and sonication. The solution was then filtered through a Pall Acrodisc 37 mm syringe filter with 1 μm glass fibre membrane to remove fines and undissolved material. The filtered solution was adjusted to a total volume of 500 ml with ethanol to give a solution with nominal concentration of 50 mg/mL.

Workup

  1. customSamples were prepared in batches
  2. temperaturewith gentle heating
  3. customsonication
  4. filtrationThe solution was then filtered through a Pall Acrodisc 37 mm syringe
  5. filtrationfilter with 1 μm glass fibre membrane
  6. customto remove fines and undissolved material
  7. customto give a solution with nominal concentration of 50 mg/mL

Sources & evidence

ORD record
ord-8c45197d316a4a7b93b250bf2246a7b8
Source dataset
uspto-grants-2014_01
Patent number
US08633319B2

Reaction notes

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