HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 473363Generated: October 30, 2026
3-Oxocyclobutane-1-carbonitrile → 3-(2-(5-Bromo-2-methoxypyridin-3-yl)-2-oxoethylidene)cyclobutanecarbonitrile
https://huagongshe.com/reaction/473363
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Oxocyclobutane-1-carbonitrile | HCID 13082390 | — |
| Reactant | lithium (Z)-1-(5-bromo-2-methoxypyridin-3-yl)-2-(dimethoxyphosphoryl)ethenolate | HCID 59468662 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(2-(5-Bromo-2-methoxypyridin-3-yl)-2-oxoethylidene)cyclobutanecarbonitrile | HCID 57515863 | — |
Reaction Steps
A mixture of lithium (Z)-1-(5-bromo-2-methoxypyridin-3-yl)-2-(dimethoxyphosphoryl)ethenolate (2.0 g, 5.8 mmol) and 3-oxocyclobutanecarbonitrile (1.1 g, 12 mmol) in p-dioxane (6 ml) was heated at 120° C. by Microwave in 1 h. The mixture was cooled, taken up in H2O, extracted with EtOAc (3×), dried over MgSO4, concentrated to provide the title compound. MS (m+11): 307.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08633315B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-f4f3713c570341ffb0c4fb1f1e1907ee |
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| Source note | uspto-grants-2014_01 |
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