Potassium Carbonate → HCID 58318635, compound

Participants

Reaction Steps

2-Chloro-3-phenyl-1,5-naphthyridine was made according to a known procedure (WO 2005/100356). A mixture of 2-chloro-3-phenyl-1,5-naphthyridine (200 mg, 0.85 mmol), diethylzinc (0.87 mL, 1 M in hexane, 1.02 eq), K2CO3 (354 mg, 3.0 eq) and PdCl2(dppf)2 DCM complex (62.5 mg, 0.1 eq) in THF (5 mL) was purged with N2 for 5 min before heating to reflux. After 6 h, the reaction was quenched with NH4Cl and extracted with EtOAc and the residue was purified by silica gel column chromatography using hexane/DCM (2/3) as eluent to give a yellow solid. LC-MS (ESI) m/z 235 [M+H]+.

Provenance & Evidence