反应详情

温度

25 °C

To a solution of 2-(1,3-dioxolan-2-yl)-5-fluoro-3-nitropyridine (10 g, 46.69 mmol) in ethanol (140 mL) was added Pd/C (1 g) under nitrogen atmosphere. The reaction mixture was stirred for overnight under hydrogen atmosphere at 25° C. The reaction mixture was filtered through Celite™ and washed with EtOH. The filtrate was concentrated in vacuo and residue was purified by column chromatography on silica gel using 0-40% EtOAc in hexane to give 2-(1,3-dioxolan-2-yl)-5-fluoropyridin-3-amine: LC-MS (ESI) m/z 185.2 [M+H]+.

1. filtrationThe reaction mixture was filtered through Celite™
2. washwashed with EtOH
3. concentrationThe filtrate was concentrated in vacuo and residue
4. customwas purified by column chromatography on silica gel using 0-40% EtOAc in hexane