Cornforth reagent → HCID 58318632, compound

Participants

Reaction Steps

To a solution of methyl (7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol (50 mg, 0.15 mmol) in DCM (0.5 mL) was added pyridinium dichromate (113 mg, 0.3 mmol) at 25° C. The reaction mixture was stirred for overnight at same temperature. The reaction mixture was filtered through Celite™. The filtrate was concentrated in vacuo to give 7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde: LC-MS (ESI) m/z 331.1 [M+H]+. It was carried on crude for next step.

Provenance & Evidence