Hydrochloric Acid → HCID 58318590, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(1-(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl) isoindoline-1,3-dione (1.2 g, 2.52 mmol in EtOH (40 mL) was added hydrazine hydrate (0.8 mL, 16.4 mmol) at 25° C. The reaction mixture was stirred for overnight at 25° C. The reaction mixture was acidified with 5 N hydrochloric acid and concentrated in vacuo. Water was added to residue and extracted with EtOAc. Aq. layer was basified with aq. NaOH solution and extracted with EtOAc. The organic layer was dried over Na2SO4 and concentrated in vacuo to give 1-(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine: LC-MS (ESI) m/z 345.96 [M+H]+. It was carried on crude for next step.

Provenance & Evidence