Cornforth reagent → 2-(2-(Methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde

Participants

Reaction Steps

To a solution of crude of methyl (2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol (1 g, 3.18 mmol) in DCM (10 mL) was added pyridinium dichromate (2.4 g, 6.36 mmol) at 25° C. The reaction mixture was stirred for overnight at same temperature. The reaction mixture was filtered through Celite™. The filtrate was concentrated in vacuo to give 2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde: LC-MS (ESI) m/z 313.0 [M+H]+. It was carried on crude for next step.

Provenance & Evidence