2-(2-(Methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde → HCID 58318628, compound

Participants

Reaction Steps

To a solution of crude of 2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde (1.0 g, 3.2 mmol) in THF (25 mL) was added methyl magnesium bromide (3.2 mL, 9.6 mmol) at 0° C. The reaction mixture was stirred for 2 h at same temperature. The reaction mixture was quenched with satd solution of ammonium chloride and extracted with EtOAc. The organic layer was dried over Na2SO4 and concentrated in vacuo to give 1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanol: LC-MS (ESI) m/z 329.0 [M+H]+. It was carried on crude for next step.

Provenance & Evidence