HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluoroaniline → HCID 45256216, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluoroaniline | HCID 9709 | — |
| Reactant | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | HCID 11155794 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | HCID 67360650 | HCID 67360650 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | HCID 45256216 | HCID 45256216 | 40% |
Reaction Steps
For the preparation of the compound by method C, 0.65 g (1.8 mmol) of 2-chloro-7-(3-acetoxypropoxy)-10,11-dihydrodibenzo[a,d]-cyclohepten-5-one, 0.25 g (1.9 mmol) of 2,4-difluoroaniline, 0.05 g (0.22 mmol) of Pd(OAc)2, 0.10 g (0.21 mmol) of 2-(dicyclohexylphosphino)-2′-,4′-,6′-triisopropyl-biphenyl, 0.70 g (6.2 mmol) of KOt-Bu, 5 ml of toluene and 1 ml of t-BuOH are used. Yield: 40%; C24H21F2NO3 (Mr=409.44)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633312B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-244e134bdc264ba7a5af84c3689f48aa |
| Source note | uspto-grants-2014_01 |