HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorobenzaldehyde → 2-[2-(3-Chlorophenyl)-vinyl]-4-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorobenzaldehyde | HCID 11477 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 2-Bromomethyl-4-methoxybenzoic acid | HCID 22594206 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[2-(3-Chlorophenyl)-vinyl]-4-methoxybenzoic acid | HCID 67497207 | — |
Reaction Steps
For the synthesis of the title compound, 45.6 g (0.186 mol) of 2-bromomethyl-4-methoxybenzoic acid, 48.8 g (0.186 mol) of triphenylphosphine, 26.1 g (0.186 mol) of 3-chlorobenzaldehyde and 84.0 g (0.435 mol) of NaOMe (28%) in 150 ml of methanol are reacted by method I. Purification is carried out by recrystallization from methanol at 4° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633312B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-57c08588096146c28ca1ab6f0fe97377 |
| Source note | uspto-grants-2014_01 |