HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 45280584, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 2,4-Difluoroaniline | HCID 9709 | — |
| Reactant | Phosphine | HCID 24404 | — |
| Reactant | HCID 67360668 | HCID 67360668 | — |
| Reactant | sodium 2-methylpropan-2-olate | HCID 178418730 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | HCID 45280584 | HCID 45280584 | — |
Reaction Steps
For the synthesis of the title compound, 0.81 g (0.0022 mol) of (S)-2-chloro-1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-10,11-dihydrodibenzo[a,d]cyclohepten-5-one, 0.25 g (0.0019 mol) of 2,4-difluoroaniline, 2 spatula tips of Pd(OAc)2, 0.14 g of phosphine ligand and 0.70 g (0.0073 mol) of NaOtert-Bu in 10 ml of toluene and 2 ml of tert-BuOH are reacted by method O. Purification is carried out by column chromatography (flash; SiO2; hexane 80%/ethyl acetate 20%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633312B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-c8110f1ad98948a2bf853b78699d6942 |
| Source note | uspto-grants-2014_01 |