HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 8-Chloro-1-(tetrahydropyran-4-yloxy)-10,11-dihydrodibenzo[a,d]cyclohepten-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Tetrahydro-4H-pyran-4-ol | HCID 74956 | — |
| Reactant | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| Reactant | HCID 67359866 | HCID 67359866 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 8-Chloro-1-(tetrahydropyran-4-yloxy)-10,11-dihydrodibenzo[a,d]cyclohepten-5-one | HCID 67362449 | 45% |
Reaction Steps
For the synthesis of the title compound, 0.45 g (1.7 mmol) of 8-chloro-1-hydroxy-10,11-dihydrodibenzo[a,d]cyclohepten-5-one, 0.28 g (0.0027 mol) of tetrahydropyran-4-ol, 0.77 g (2.9 mmol) of P(Ph)3 and 0.41 g (2.0 mmol) of diisopropyl azodicarboxylate in 2 ml of THF are reacted by method P. C20H19ClO3 (Mr=342.83); yield: 45%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633312B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-26541f1f53934afca33467f209ffeacd |
| Source note | uspto-grants-2014_01 |