1-Bromo-2-nitrobenzene → 3-(2-Nitrophenylamino)-8-nitro-6H-dibenzo[b,e]oxepin-11-one

Participants

Reaction Conditions

Reaction Steps

In accordance with general method Z, 1.00 g (3.70 mmol) of (6), 0.80 g (3.96 mmol) of 1-bromo-2-nitrobenzene, 2 spatula tips of Pd(OAc)2, 0.10 g of 2-(dicyclohexylphosphino)-2′,4′,6′-triisopropylbiphenyl (phosphine ligand), 0.70 g of KOt-Bu, 2.0 ml of t-BuOH are weighed out and dissolved in 10 ml of toluene (anhydrous). The mixture is refluxed at 100° C. under an argon atmosphere for 4 h. The crude product is purified by chromatography over silica gel with MC/EtOH (98/2). Yield 0.35 g (24.2%); melting point: 212.5° C.

Provenance & Evidence