2-Bromoanisole → 3-(2-Methoxyphenylamino)-8-nitro-6H-dibenzo[b,e]oxepin-11-one

Participants

Reaction Conditions

Reaction Steps

In accordance with general method Z, 0.80 g (2.96 mmol) of (6), 0.70 g (3.80 mmol) of 2-bromoanisole, 2 spatula tips of Pd(OAc)2, 0.10 g of 2-(dicyclohexylphosphino)-2′,4′,6′-triisopropylbiphenyl (phosphine ligand), 0.50 g of KOt-Bu, 2.0 ml of t-BuOH are weighed out and dissolved in 10 ml of toluene (anhydrous). The mixture is refluxed at 100° C. under an argon atmosphere for 4 h. The crude product is purified by chromatography over silica gel with MC/EtOH (98/2). Yield: 0.025 g (2.2%); melting point: 200.3° C.

Provenance & Evidence