4-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotoluene → 8-Nitro-3-(2-nitro-4-trifluoromethylphenylamino)-6H-dibenzo[b,e]oxepin-11-one

Participants

Reaction Conditions

Reaction Steps

In accordance with general method Z, 0.70 g (2.60 mmol) of (6), 0.55 g (3.05 mmol) of 4-chloro-3-nitro-benzotrifluoride, 2 spatula tips of Pd(OAc)2, 0.10 g of 2-(dicyclohexylphosphino)-2′,4′,6′-triisopropylbiphenyl (phosphine ligand), 0.50 g of KOt-Bu, 2.0 ml of t-BuOH are weighed out and dissolved in 10 ml of toluene (anhydrous). The mixture is refluxed at 100° C. under an argon atmosphere for 4 h. The crude product is purified by chromatography over silica gel with n-hexane/ethyl acetate (5/2). Yield: 0.047 g (3.9%);

Provenance & Evidence