HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-tert-butyl 4-(3-(5-(2-(tert-butoxycarbonylamino)pent-4-ynamido)pent-1-ynyl)phenoxy)piperidine-1-carboxylate | HCID 86653106 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | (S)-2-amino-N-(5-(3-(piperidin-4-yloxy)phenyl)pent-4-ynyl)pent-4-ynamide | HCID 52919595 | — |
Reaction Steps
To a stirring solution of (S)-tert-butyl 4-(3-(5-(2-(tert-butoxycarbonylamino)pent-4-ynamido)pent-1-ynyl)phenoxy)piperidine-1-carboxylate (0.26 g, 0.47 mmol) in dichloromethane (4.0 ml), TFA (1.0 ml) was added. The resulting solution was stirred at room temperature for 1 hr, then concentrated. The resulting residue was purified over Gilson HPLC to yield the title compound as its corresponding TFA salt, as a white solid. MH+ 354.31
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08633322B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-44c1f563802e4333806e24a46bbf6c82 |
| Source note | uspto-grants-2014_01 |