Hydrazine hydrate (1:1) → HCID 67203526, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 4-(3-(5-(1,3-dioxoisoindolin-2-yl)pent-1-ynyl)-5-methoxyphenoxy)piperidine-1-carboxylate (0.500 g, 0.97 mmol) and hydrazine monohydrate (0.094 mL, 1.94 mmol) were taken up into ethanol (5 mL) and the resulting mixture was stirred at 80° C. for 2.5 hours. The resulting mixture was filtered and the solvent was removed in vacuo to yield tert-butyl 4-(3-(5-aminopent-1-ynyl)-5-methoxyphenoxy)piperidine-1-carboxylate. MH+ 388.2

Provenance & Evidence