1,2-Dibromoethane → HCID 86676883, compound

Participants

Reaction Steps

tBuOK (5 g, 44 mmol) was added in portions to a suspension of 4-nitroimidazole in anhydrous DMF (100 mL) at 0° C., then the reaction mixture was stirred at r. t. for 3 h, a solution of 1,2-dibromoethane in anhydrous DMF (20 mL) was added into the above mixture. The reaction solution was stirred at r. t. for 3 days, and was poured into ice-water (200 mL) for standing up for 2 h, then filtered. The filtered cake was washed with EtOH/CH2Cl2 (1/1) and dried to provide 64 (2.3 g, 45%) as off-white solid, which was pure enough to be used next step.

Provenance & Evidence