HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 7,9-dichloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Cyclopentadiene | HCID 7612 | — |
| Reactant | 3,5-Dichloroaniline | HCID 12281 | — |
| Reactant | 2-Ketobutyrate | HCID 3593277 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 7,9-dichloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid ethyl ester | HCID 9883225 | 89% |
Reaction Steps
Compound 1 was prepared in a yield of 89% by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol cyclopentadiene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699877B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-c93fb06d75a54a20946d718092cdbc12 |
| Source note | uspto-grants-2004_03 |