2-(1-Benzylpyrrolidin-3-yl)propan-2-ol → 2-(Pyrrolidin-3-yl)propan-2-ol

HRID 473618Notes

Reaction equation

HRID 473618 reaction equation
C([N:8]1[CH2:12][CH2:11][CH:10]([C:13]([OH:16])([CH3:15])[CH3:14])[CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].CCO>[NH:8]1[CH2:12][CH2:11][CH:10]([C:13]([OH:16])([CH3:15])[CH3:14])[CH2:9]1

Participants

5

Reactant 2

HCID 69147642-(1-Benzylpyrrolidin-3-yl)propan-2-olHCID 178418361HCID 178418361, compound

Product 1

HCID 139001662-(Pyrrolidin-3-yl)propan-2-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A pressure vessel was charged with 2-(1-benzylpyrrolidin-3-yl)propan-2-ol (1.013 g, 4.62 mmol), palladium, 10 wt. % (dry basis) on activated carbon (wet) (0.904 g, 0.425 mmol) and EtOH (20 mL). The reaction vessel was pressurized (50 psi) with hydrogen and purged 3 times. The vessel was pressurized at 50 psi and allowed to stir overnight at rt. The reaction was filtered and the filtrate was concentrated to dryness.

Workup

  1. custompurged 3 times
  2. filtrationThe reaction was filtered
  3. concentrationthe filtrate was concentrated to dryness

Sources & evidence

ORD record
ord-29d3792d19f94b2ebb50d098a63ef16a
Source dataset
uspto-grants-2014_01
Patent number
US08637500B2

Reaction notes

Loading…