HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 8-chloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Cyclopentadiene | HCID 7612 | — |
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | 2-Ketobutyrate | HCID 3593277 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 8-chloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid ethyl ester | HCID 9965449 | 89% |
Reaction Steps
Compound 3 was prepared in a yield of 89% by the basic process from 5.0 mmol 4-chloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol cyclopentadiene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699877B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-0a43b64858bc4a909c3d85b6456cc7da |
| Source note | uspto-grants-2004_03 |