HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 473630Generated: October 30, 2026
Sodium Carbonate → N-(4-(2'-Methoxy-3,4'-bipyridin-2-yloxy)phenyl)-5-methylpyridin-2-amine
https://huagongshe.com/reaction/473630
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (2-Methoxypyridin-4-yl)boronic acid | HCID 23546919 | — |
| Reactant | N-(4-(3-bromopyridin-2-yloxy)phenyl)-5-methylpyridin-2-amine | HCID 59374189 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | N-(4-(2'-Methoxy-3,4'-bipyridin-2-yloxy)phenyl)-5-methylpyridin-2-amine | HCID 59373944 | — |
Reaction Steps
To a glass microwave vial was added N-(4-(3-bromopyridin-2-yloxy)phenyl)-5-methylpyridin-2-amine (0.2017 g, 0.566 mmol), 2-methoxypyridin-4-ylboronic acid, trans-dichlorobis(triphenylphosphine) palladium (II) (0.032 g, 0.045 mmol), and sodium carbonate (0.300 g, 2.83 mmol) in DME (0.906 mL) and water (0.226 mL). The reaction mixture was stirred and heated in a Biotage Initiator microwave reactor at 100° C. for 30 min. The crude product was purified by chromatography to give the title compound. MS (ESI, pos. ion) m/z: 356 (M+1). IC50 (uM) 0.003548.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637500B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-5121359e4e0344cf8debf579a34614de |
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| Source note | uspto-grants-2014_01 |
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