Boron tribromide → HCID 59374178, compound

Participants

Reaction Conditions

Reaction Steps

The solution of 3-fluoro-N-(4-methoxyphenyl)pyridin-2-amine (0.50 g, 0.002 mol) in DCM (20 mL) was cooled to −40° C. and to it was added boron tribromide (1.14 g, 0.0045 mol) dropwise under nitrogen over 30 mins. The reaction mixture was stirred at −40° C. for 1 h then at RT for another 2 h. The reaction mixture was cooled at 0° C. and saturated sodium bicarbonate was added. After stirring for 30 mins, the reaction was extracted with ethyl acetate (20×3 mL). Combined organic extracts were dried over sodium sulfate and concentrated to give the desired product which was used directly in the next step. MS (ESI, pos. ion) m/z: 205.19 (M+1).

Provenance & Evidence