HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1,3-Dichloro-5,6,6a,7,8,12b-hexahydrobenzo[k]phenanthridine-6-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1,2-Dihydronaphthalene | HCID 9938 | — |
| Reactant | 3,5-Dichloroaniline | HCID 12281 | — |
| Reactant | 2-Ketobutyrate | HCID 3593277 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1,3-Dichloro-5,6,6a,7,8,12b-hexahydrobenzo[k]phenanthridine-6-carboxylic acid ethyl ester | HCID 10199516 | 85% |
Reaction Steps
Compound 12 was prepared in a yield of 85% by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 1,2-Dihydronaphthalene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699877B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-3d54656f7e5948219183190a4e02e3bf |
| Source note | uspto-grants-2004_03 |