4-(2-fluoropyridin-3-yl)-1-methyl-5,6-dihydropyridin-2(1H)-one → 4-(2-Fluoropyridin-3-yl)-1-methylpiperidin-2-one

HRID 473723노트

반응식

HRID 473723 반응식
[F:1][C:2]1[C:7]([C:8]2[CH2:13][CH2:12][N:11]([CH3:14])[C:10](=[O:15])[CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1>O1CCCC1.[Pd]>[F:1][C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][N:11]([CH3:14])[C:10](=[O:15])[CH2:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 1

HCID 593269334-(2-fluoropyridin-3-yl)-1-methyl-5,6-dihydropyridin-2(1H)-one

생성물 1

HCID 593270104-(2-Fluoropyridin-3-yl)-1-methylpiperidin-2-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 4-(2-fluoropyridin-3-yl)-1-methyl-5,6-dihydropyridin-2(1H)-one (0.067 g, 0.32 mmol) in tetrahydrofuran (1.6 mL) was added palladium, 10 wt. % on activated carbon (0.035 g, 0.032 mmol) and hydrogenated (double-walled balloon pressure) at 40° C. for 3 h. The mixture was filtered via a pad of Celite, and the filtrate was concentrated in vacuo to give a relatively pure crop of 4-(2-fluoropyridin-3-yl)-1-methylpiperidin-2-one as a milky oil. MS (ESI, pos. ion) m/z: 209.0 (M+1).

후처리

  1. filtrationThe mixture was filtered via a pad of Celite
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-86f34a66f8a848d5bb8ddf7ba726b011
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637500B2

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