Acetic Anhydride → HCID 59373920, compound

Participants

Reaction Steps

To 2-fluoro-3-(pyrrolidin-3-yl)pyrazine (0.2 g, 1.2 mmol) dissolved in DCM (2.4 mL) was added acetic anhydride (0.56 mL, 6.0 mmol) and sodium bicarbonate (0.502 g, 5.98 mmol). The reaction mixture was stirred at RT under N2 for 3 h. The reaction mixture was partitioned between 1N NaOH and DCM. The aqueous layer was back extracted with DCM (3×) and the combined DCM layer was washed with brine, dried (Na2SO4) and concentrated to provide 1-(3-(3-fluoropyrazin-2-yl)pyrrolidin-1-yl)ethanone as a yellow oil. MS (ESI, pos. ion) m/z: 210.0 (M+1).

Provenance & Evidence