Cesium carbonate → HCID 59374056, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(pyridin-2-ylamino)phenol (0.30 g, 1.60 mmol), cesium carbonate (1.56 g, 4.80 mmol), and 2-chloro-3-cyclopentylpyrazine (0.29 g, 1.60 mmol) under argon was heated to 120° C. for 20 h. The mixture was cooled to RT and partitioned between ethyl acetate and water. The layers were separated and the organic layer was washed with aqueous 1N sodium hydroxide (2×), saturated aqueous sodium chloride (1×), dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. The resulting oil was purified by silica gel chromatography to give N-(4-(3-cyclopentylpyrazin-2-yloxy)phenyl)pyridin-2-amine. MS (ESI, pos. ion) m/z: 333.3 (M+1). IC50 (uM) 0.012.

Provenance & Evidence