HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5,7-Dichloro-4-p-tolyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-Ethenyl-4-methylbenzene | HCID 12161 | — |
| Reactant | 3,5-Dichloroaniline | HCID 12281 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Ketobutyrate | HCID 3593277 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5,7-Dichloro-4-p-tolyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acid | HCID 9902295 | — |
Reaction Steps
Compound 20 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 4-methylstyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699877B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-a143d2b5e5ac4c2996929dc839306c84 |
| Source note | uspto-grants-2004_03 |