HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(Trifluoromethyl)-4-piperidinol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-hydroxy-4-(trifluoromethyl)piperidine-1-carboxylate | HCID 22061329 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Trifluoromethyl)-4-piperidinol | HCID 17951321 | 100.1% |
Reaction Steps
To a solution of tert-butyl 4-hydroxy-4-(trifluoromethyl)piperidine-1-carboxylate (0.07 g, 0.26 mmol) in dichloromethane (1 mL) was added trifluoroacetic acid (1 mL). The resulting mixture was stirred at room temperature for 30 minutes. Concentration and drying afforded 4-(trifluoromethyl)piperidin-4-ol (0.044 g, 100%). MS (EI) for C6H10F3NO: 269 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637499B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-d5b6dad348254f1ca77bc12e6316ee05 |
| Source note | uspto-grants-2014_01 |