Benzyl 2,4-diphenylpiperazine-1-carboxylate → 1,3-Diphenylpiperizine

Participants

Reaction Steps

A solution of benzyl 2,4-diphenylpiperazine-1-carboxylate (0.17 g, 0.45 mmol) and 5% Pd on carbon (0.1 g) in tetrahydrofuran/methanol 5:1 (10 mL) was stirred under hydrogen (1 atm) for 4.5 hours. The reaction was filtered through celite and concentrated to give the title compound 1,3-diphenylpiperizine (0.10 g, 93% yield) as an oil. MS (EI) for C16H18N2: 239 (MH+).

Provenance & Evidence