Triethylamine → HCID 178461685, compound

Participants

Reaction Steps

A mixture of 4-{(S)-1-[(S)-6-(2-hydroxy-2-methyl-propyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}-benzonitrile (0.50 g), hydroxylamine hydrochloride (0.18 g), and NEt3 (0.43 mL), and methanol (10 mL) was stirred at reflux temperature for 5 h. After cooling to room temperature, the solvent was evaporated, mixture was concentrated, ethyl acetate was added to the residue, and the resulting mixture was washed with water and brine. The organic solution was dried Na2SO4) and concentrated and the residue was purified by chromatography on silica gel (CH2Cl2/MeOH 98:2->93:7) to afford the title compound as a foam-like solid.

Provenance & Evidence