HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 473944Generated: October 30, 2026
Isobutylene oxide → 4-Bromo-1-(2-hydroxy-2-methylpropyl)-2(1H)-pyridinone
https://huagongshe.com/reaction/473944
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isobutylene oxide | HCID 11208 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-1-(2-hydroxy-2-methylpropyl)-2(1H)-pyridinone | HCID 59635730 | — |
Reaction Steps
A mixture of 4-bromo-1H-pyridin-2-one (0.25 g), 2,2-dimethyl-oxirane (0.26 mL), and potassium carbonate (0.40 g) in dimethylformamide (2.5 mL) was stirred under microwave irradiation at 120° C. for 30 min. After cooling to ambient temperature, the mixture was concentrated and purified by HPLC on reversed phase (acetonitrile/water) to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637505B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-174f156b0285461298abf5b5c9e29eb8 |
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| Source note | uspto-grants-2014_01 |
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