Phenyl isocyanate → HCID 58577872, compound

Participants

Reaction Steps

Phenyl isocyanate (16.1 μL, 0.148 mmol) was added at room temperature to a solution of methyl 3-(5-(3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)pyridin-2-yloxy)-2,2-dimethylpropanoate B-2 (39.2 mg, 0.114 mmol) in anhydrous methylene chloride (0.57 mL) under an atmosphere of argon. The reaction mixture was stirred overnight, then concentrated to dryness under reduced pressure to give crude methyl 2,2-dimethyl-3-(5-(4-(phenylcarbamoyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)pyridin-2-yloxy)propanoate B-3 (62.0 mg), which was sufficiently pure to be used for the next step without additional purification. MS (ESI), [M+1]+ 462.

Provenance & Evidence