Lithium hydroxide, monohydrate → HCID 58577796, compound

Participants

Reaction Conditions

Reaction Steps

Lithium hydroxide monohydrate (16.4 mg, 0.39 mmol) was added at room temperature to a solution of methyl 3-(5-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)pyridin-2-yloxy)-2,2-dimethylpropanoate B-21 (50.4 mg, 0.13 mmol) in 1,4-dioxane (2.0 mL) and water (1.0 mL). The reaction mixture was heated at 60° C. for 2 h and then concentrated to dryness under reduced pressure. The residue was purified by flash column chromatography on C18 reverse phase (water:acetonitrile gradient with 0.05% formic acid) to give 3-(5-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)pyridin-2-yloxy)-2,2-dimethylpropanoic acid B-22 (27.0 mg, Yield=56%). 1H NMR (500 MHz, METHANOL-d4) δ ppm 1.33 (s, 6H), 4.13 (m, 2H), 4.35 (s, 2H), 4.85 (m, 2H), 6.90 (d, J=8.83 Hz, 1H), 7.71 (d, J=8.83 Hz, 1H), 8.16 (s, 1H), 8.29 (s, 1H); MS (ESI) [M+1]+ 374.

Provenance & Evidence