反应详情

Intermediate 4 (18.5 g, 56.33 mmol) was added to a suspension of Raney Nickel (2 g) in a 7 N ammonia solution in MeOH (250 mL). The reaction mixture was stirred at 14° C. under hydrogen atmosphere until 2 equivalents of hydrogen were absorbed. The catalyst was removed by filtration over diatomaceous earth. The solvent was evaporated, yielding Intermediate 5 quantitatively. Intermediate 5 was used without further purification.

1. customwere absorbed
2. customThe catalyst was removed by filtration over diatomaceous earth
3. customThe solvent was evaporated