HCID 67088543, compound → HCID 67358143, compound

HRID 473979Notes

Reaction equation

HRID 473979 reaction equation
C([N:8]1[CH2:13][C@H:12]([CH3:14])[O:11][C@H:10]([C:15]([F:18])([F:17])[F:16])[CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[F:18][C:15]([F:16])([F:17])[C@H:10]1[O:11][C@@H:12]([CH3:14])[CH2:13][NH:8][CH2:9]1

Participants

5

Reactant 2

HCID 67088543HCID 67088543, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67358143HCID 67358143, compoundYield 77%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

N-benzyl-cis-2-trifluoromethyl-6-methylmorpholine [679839-97-5] (6.2 g, 23.91 mmol) was added to a suspension of Pd/C 10% (1 g) in methanol (150 mL). The reaction mixture was stirred at room temperature under a hydrogen atmosphere until 1 equivalent of hydrogen was absorbed. The catalyst was removed by filtration over diatomaceous earth. The solvent was evaporated, yielding 3.1 g (77%) of Intermediate 29 as an oil that was used without further purification.

Workup

  1. customwas absorbed
  2. customThe catalyst was removed by filtration over diatomaceous earth
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-21ff3aa2903d4e428bcaa151ca76c97e
Source dataset
uspto-grants-2014_01
Patent number
US08637510B2

Reaction notes

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