Glyoxylic Acid → 8-chloro-4-(4-propoxyphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

HRID 47418Notes

Reaction equation

HRID 47418 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9]([OH:13])(=[O:12])[CH:10]=O.[CH2:14]([O:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[CH2:23])=[CH:20][CH:19]=1)[CH2:15][CH3:16]>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:3]=1[NH:4][CH:10]([C:9]([OH:13])=[O:12])[CH2:23][CH:22]2[C:21]1[CH:24]=[CH:25][C:18]([O:17][CH2:14][CH2:15][CH3:16])=[CH:19][CH:20]=1

Participants

4

Procedure

Compound 74 was prepared from 2-chloroaniline, glyoxylic acid and 4-propoxystyrene by the automated process.

Sources & evidence

ORD record
ord-08ab1c65421b42068977880a2f9ecd1c
Source dataset
uspto-grants-2004_03
Patent number
US06699877B2

Reaction notes

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