Acetic Acid → HCID 131731169, compound

Participants

Reaction Steps

H-L-Lys(Boc)-L-Glu(OBzl)-OH (23.0, 0.05 mol) was dissolved in 100 ml of pyridine and refluxed for 4 hours. The reaction was monitored by TLC using the system of CHCl3:MeOH: 32% AcOH=5:3:1. After completion of the reaction, the mixture was evaporated in vacuum and 500 ml of 0.1% AcOH was added. The cyclo-L-Lys(Boc)-L-Glu(OBzl) was precipitated. The precipitate was filtered off, washed with water and dried in a vacuum oven at 40° C. The yield was 20.9 (86%). Rf=0.75 (CHCl3:MeOH: 32% AcOH=5:3:1); HPLC data: retention time 19.2 min.

Provenance & Evidence