HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 46837081, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | N-Acetyl-L-valine | HCID 66789 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 67439967 | HCID 67439967 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 46837081 | HCID 46837081 | — |
Reaction Steps
100 mg (0.23 mmol) of 2-{3-[5-(2-aminoethoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one hydrochloride, 43 mg (0.25 mmol) of (S)-2-acetylamino-3-methylbutyric acid, 66 mg (0.34 mmol) of EDCI, 41 mg (0.30 mmol) of HOBt are dissolved in 2 ml of DMF, and 76 μl (0.68 mmol) of 4-methylmorpholine are added. The reaction mixture is stirred at room temperature for 18 h, water is added, and the precipitate is stirred with methanol and dichloromethane. The product is dried in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637518B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-5a5a886d25454b0483bd85a4cd156513 |
| Source note | uspto-grants-2014_01 |