Hydrochloric Acid → HCID 67416785, compound

Participants

Reaction Conditions

Reaction Steps

130 mg (0.185 mmol) of 3-(6-oxo-1-{3-[5-(piperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}-1,6-dihydropyridazin-3-yl)benzonitrile (liberated from the hydro-chloride by suspension in THF and extraction with 1N NaOH)), 28 μl (0.37 mmol) of cyclopropanecarboxaldehyde and 78 mg (0.37 mmo) of sodium triacetoxyborohydride are dissolved in 10 ml of THF, and 200 μl of acetic acid are added. The reaction mixture is stirred at 40° C. for 15 h. The reaction mixture is filtered and washed with THF. The filtrate is evaporated and purified by means of preparative HPLC.

Provenance & Evidence