Pyridine → HCID 67442688, compound

Participants

Reaction Steps

1.14 g (3 mmol) of 3-{1-[3-(5-hydroxypyrimidin-2-yl)benzyl]-6-oxo-1,6-dihydropyridazin-3-yl}benzonitrile are suspended in 15 ml of dichloromethane, 242 μl [3 mmol) of pyridine are added, and 3.0 ml of 1 M isopropyl chloroformate solution in toluene are added dropwise at 0-5° C. with stirring. The mixture is stirred at room temperature for 24 h. The reaction mixture is filtered, the mother liquor is washed with water, dried, filtered and stripped off to dryness. The residue is purified by column chromatography on silica gel. The product is triturated with ether, filtered off with suction and dried.

Provenance & Evidence