Acetic Acid → HCID 46836601, compound

Participants

Reaction Conditions

Reaction Steps

150 mg (0.22 mmol) of 3-(6-oxo-1-{3-[5-(piperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}-1,6-dihydropyridazin-3-yl)benzonitrile is suspended in 5 ml of acetone, and 94 mg (0.45 mmol) of sodium triacetoxyborohydride are added. 200 μl of acetic acid are added to the reaction mixture, which is then stirred at 40° C. for 15 h. A further 94 mg (0.45 mmol) of sodium triacetoxyborohydride are subsequently added, and the mixture is stirred at 40° C. for 24 h. The reaction mixture is filtered, and the residue is washed with THF. The filtrate is stripped off to dryness and purified by means of preparative HPLC.

Provenance & Evidence