Formaldehyde → HCID 46836602, compound

Participants

Reaction Conditions

Reaction Steps

1.25 g (2.1 mmol) of tert-butyl 4-(2-{3-[3-(3-carbamoylphenyl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxymethyl)piperidine-1-carboxyl-ate are dissolved in 6 ml of formic acid, and 500 μl (6.3 mmol) of 35% formaldehyde solution in water are added. The reaction mixture is stirred at 110° C. for 48 h. The reaction mixture is evaporated, taken up in dichloro-methane, washed with saturated sodium hydrogencarbonate solution, dried over sodium sulfate and purified by means of column chromatography on silica gel. ESI: 511 (M+H);

Provenance & Evidence